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Nobel Conference 2018

/Nobel Conference 2018
Nobel Conference 20182018-12-12T14:11:59+00:00

Nobel Conference 2018: Epithelial-Mesenchymal Plasticity in Cancer Metastasis

Date: December 13-14, 2018
Place: Nobel Forum, Nobels Väg 1, Karolinska Institutet

The aim of the Nobel Conference 2018 is to highlight the tremendous progress, which has been seen during the last decade, in understanding how epithelial-mesenchymal plasticity influences the capacity of epithelial cancers to metastasize.

Preliminary program

Thursday December 13, 2018:

08.00 – 09.00 Registration
09.00 – 09.15 Welcome to the Conference

Session I; Transcriptional control of EMT
09.15 – 10.00 Keynote Lecture: Angela Nieto, Instituto de Neurociencias, Spain
10.00 – 10.30 Geert Berx, University of Gent, Belgium ZEB Proteins Dictate Cellular Plasticity during Tissue Homeostasis, Cancer Initiation and Progression
10.30 – 10.45 Coffee
10.45 – 11.15 Amparo Cano, University of Madrid, Spain LOXL2 & E2A: Novel regulators of tumor cell plasticity and metastasis
11.15 – 11.45 Antonio Garcia de Herreros, IMIM, Barcelona, Spain Controlling Snail1 function during EMT and fibroblast activation
11.45 – 12.45 Lunch

Session II; Translational mechanisms of cancer cell plasticity
12.45 – 13.15 Soheil Tavazole, Rockefeller University, USA Molecular mechanisms underlying metastatic colonization
13.15 – 13.45 Robert Schneider, NYU Cancer Institute, USA Translational regulation of breast cancer metastasis and the cancer stem cell
13.45 – 14.15 Theresa Vincent, Uppsala University/Weill Cornell University Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
14.30 – 15.00 Scott Blanchard, Weill Cornell Medical University, USA Could the ribosome itself contribute to EMT?
15.00 – 15.30 John Blenis, Weill Cornell Medical University, USA
15.30 – 16.00 Coffee

Session IV; Imaging cancer cell plasticity during invasion and metastasis
16.00 – 16.30 Peter Friedl, University of Würzburg Invasion programs and EMT
16.30 – 17.00 Jacco van Rheenen, Hubrecht Institute, Utrecht EMT plasticity during the metastatic cascade: intravital microscopy insights
17.00 – 17.30 Andrew Ewald, Johns Hopkins University School of Medicine Molecular programs of migration, invasion, and metastasis in epithelial organ

Friday December 14, 2018:

Session II; Cell plasticity in cancer metastasis

09.00 – 09.45 Keynote Lecture: Robert Weinberg, MIT, Boston
09.45 – 10.15 Yibin Kang, Princeton University, USA The dynamics of epithelial-mesenchymal plasticity and its impact on metastasis
10.15 – 10.45 Ben Z. Stanger, University of Pennsylvania, USA Epithelial-mesenchymal plasticity in carcinomas is governed by at least two distinct programs
10.45 – 11.15 Cédric Blanpain, University of Brussels, Belgium EMT tumour transition states
11.15 – 11.30 Coffee

Session III; TGF-beta signaling in EMT and cancer metastasis
11.30 – 12.00 Rik Derynck, University of California San Francisco TGF-beta-induced reversible versus stabilized EMT
12.00 – 12.30 Philip Howe, University of South Carolina, USA Transforming growth factor beta -mediated epithelial-mesenchymal transitions
12.30 – 13.00 Aris Moustakas, Uppsala University TGFβ and EMT transcription factor signaling loops
13.00 – 13.30 Jonas Fuxe, Karolinska Institutet Molecular switches controlling TGF-beta-induced EMT
13.30 – 14.30 Lunch

Session V; Plasticity and systemic spread of cancer
14.30 – 15.00 David Lyden, Weill Cornell Medical College, NY Tumor exosome subpopulations and exomeres promote cancer metastasis and systemic disease
15.00 – 15.30 Shyamala Maheswaran, Massachusetts Gen. Hospital, Cancer Center Epithelial to Mesenchymal Transition: A Dynamic Process Contributing to Genomic Diversity
15.30 – 16.00 Sandra McAllister, Harvard Medical School, USA Systemic Inflammation Regulates Plasticity and Determines the Fate of Metastatic Breast Cancer Cells
16.00 – 16.15 Coffee

Session VII; Exploring EMT as a therapeutic target
16.15 – 16.45 Thomas Brabletz, Germany Cell Plasticity in Cancer Metastasis: Driving Force and Therapeutic Target
16.45 – 17.15 Erik Thompson, University of Technology, Queensland, Australia Epithelial-mesenchymal plasticity in therapy resistance and metastatic progression in breast cancer
17.15 – 17.45 Gerhard Christofori, University of Basel, Switzerland
17.45 – 18.15 Maja Oktay, Albert Einstein College, USA Biology of the pro-metastatic breast cancer microenvironment – how to assess it and who may be at risk