The Nobel Prize in Physiology or Medicine will be announced Monday October 3 at 11.30 at earliest, Nobel Forum, Nobels väg 1, 171 77 Stockholm.
Registration and press id is required to attend the Press Conference.
When the Secretary General begins his announcement at the Press Conference, the following information material will become available at www.nobelprizemedicine.org and at www.nobelprize.org:
- Open webcast from the Press Conference
• Press releases in English and Swedish
• Scientific background in English
• Illustrations, web links and further reading
At the venue several experts will be available for interviews in Swedish or English (5-10 minutes), please indicate in the registration.
Research Lecture at Nobel Forum
Date: 13 October, kl. 16.30
Speaker: Michael J. Berridge, The Babraham Institute, University of Cambridge, Cambridge, UK
Title: “Inositol trisphosphate, calcium and Vitamin D signalling in health and disease”
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by different signalling pathways. One of these is the inositol trisphosphate/calcium (InsP3/Ca2+) signalling pathway that operates through either primary or modulatory mechanisms. In its primary role, it generates the Ca2+ that acts directly to control many cellular processes. Its modulatory role occurs in excitable cells where it modulates the primary Ca2+ signal generated by the entry of Ca2+ through voltage-operated channels. In carrying out this modulatory role, the InsP3/Ca2+ signalling pathway induces subtle changes in the generation and function of the voltage-dependent primary Ca2+ signal. Changes in the nature of both the primary and modulatory roles of InsP3/Ca2+ signalling are a contributory factor responsible for the onset of many human pathologies such as Alzheimer’s disease and heart disease. Many of these diseases can be prevented by Vitamin D that acts to maintain Ca2+ homeostasis.